Over the last several decades the role of chemistry in small molecule drug discovery has changed dramatically. The function that chemists fill in R&D efforts have become more diverse, complex and specialized, all at the same time.  However, at the end of the day an effective small molecule drug is a chemical with a very specialized set of properties that allow it to be safely administered to people. Using examples from 30+ years of Drug Discovery this talk will illustrate how from a starting point at which synthetic organic chemistry was the �core� chemical science it is now but one part of a complex amalgam.   Now the medicinal chemist is more of a conductor/composer who designs and develops a drug via the integration of input from synthetic, analytical, computational, structural biological, physical, and informatics chemists.

Evolving role of chemistry in small molecule drug discovery

244th National Meeting (2012)

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