When tissues are exposed to Inflammatory stimuli such as bacterial infections, inflammatory cells,  including macrophages and neutrophils migrate to and invade the infected or damaged tissue. In a mouse model of inflammatory bowel disease (IBD) and colon cancer, bacterial infection leads sequentially to chronic inflammation, dysplasia and cancer, by a process that is promoted by pro-inflammatory cytokines/chemokines,  oxidative and nitrosative stress and DNA/protein damage. The invading inflammatory cells produce a complex mixture of chemicals, including NO, H2O2 , HO�,  CO3-�, HOCl,  and NO2�, which damage and lead to degradation of proteins, lipids and nucleic acids, ultimately inducing mutation and/or cell death.  Mass spectrometric analysis of protein and nucleic acid damage in the mouse and human validates the model. Application of the results to the discovery of serum biomarkers of the disease can monitor disease severity and activity in IBD patients.

Chemistry of inflammation and cancer: Lessons from inflammatory bowel disease

244th National Meeting (2012)

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