Medicinal chemistry involves an iterative process of design, synthesis, biological assay and analysis of molecules to feed into the next learning cycle.  Cyclofluidic is developing an integrated microfluidic platform enabling the automated and rapid generation of SAR data in medicinal chemistry.   A key element of this approach is the ability to close the loop i.e. utilising the biological data as it is generated in the design of the next iteration of synthesis and screening.  A number of design methods have been developed, including simple maximising potency and multi-parameter optimisation to apply to different medicinal chemistry scenarios.  An overview of the Cyclofluidic approach will be provided with a particular focus on the design methods, their validation and use on the platform.

Intersection of chemists, computers, and automation: A fully integrated approach to SAR generation

244th National Meeting (2012)

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