Magnetic resonance imaging (MRI) is a versatile and commonly employed technique for the diagnosis of disease. However, because it typically utilizes endogenous proton signals, MRI suffers from poor contrast. As such, approximately 50% of MRI procedures are performed using gadolinium chelates, which enhance contrast but do not readily identify biomolecular targets at sub-mM concentrations. Hyperpolarized (HP) nuclei, such as HP 13C and 129Xe offer potential advantages in sensitivity and molecular specificity. Our lab has developed xenon biosensors exploiting the favorable association between 129Xe and water-soluble cryptophane cages. The chemical shift of encapsulated xenon can be strongly perturbed by even small changes in its microenvironment. Therefore, functionalization of the cryptophane allows for multiplexed detection of disease biomarkers. We have designed cryptophane-peptide conjugates that specifically target integrin receptors as well as other biologically relevant species.

Peptide-conjugated cryptophanes: Targeted <sup>129</sup>Xe biosensors

244th National Meeting (2012)

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Peptide-conjugated cryptophanes: Targeted 129Xe biosensors

Peptide-conjugated cryptophanes: Targeted ¹²⁹Xe biosensors