Sodium channel inhibitor (SCI) insecticides were discovered almost four decades ago, but have only recently yielded important commercial products (e.g., indoxacarb and metaflumizone). SCI insecticides inhibit sodium channel function by binding selectively to slow-inactivated (non-conducting) sodium channel states. Characterization of the action of SCI insecticides on mammalian sodium channels using both biochemical and electrophysiological approaches demonstrates that they bind at or near a drug receptor site, the local anesthetic receptor. This mechanism and site of action on sodium channels differentiates SCI insecticides from pyrethroids, lipid amides, and other insecticidal agents that act on sodium channels. However, SCI share a common mode of action with drugs currently under investigation as anticonvulsants and treatments for neuropathic pain. The properties that distinguish therapeutic and toxic state-dependent SCIs remain to be identified.

Sodium channel inhibitor insecticides: Blurring the line between insecticides and drugs

244th National Meeting (2012)

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