We attempted to develop a highly sensitive magnetic resonance (MR) probe for investigation of biological function in vivo. To this end, we took advantage of hyperpolarization method. The hyperpolarization is a highly promising method to enhance MR signals dramatically. However, the hyperpolarization method has non-negligible shortcomings, i.e., the short lifetime of the polarized spin state in solution. Therefore, we explored the molecular units having long hyperpolarization lifetime and discovered a promising candidate. By utilizing the unit, we designed a sensitive MR probe as targeting metal ions. Here we report the details of exploration of molecular structures with a long hyperpolarization lifetime and its application for sensitive magnetic resonance probe.

Exploration of molecular structures having a long hyperpolarization lifetime and its application for highly sensitive magnetic resonance probe

244th National Meeting (2012)

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