Nanotechnology has emerged as a powerful new platform for the pharmaceutical industry and has had a significant impact on drug development from preclinical studies to commercial marketed products.  For example, increasing drug exposures in preclinical species has been a formulation challenge in addressing safety issues of drug candidates and nanosuspensions provide a potential technology to achieve this while providing line of sight into development. Drug nanoparticles have unique properties that can provide advantages for drug delivery.  Due to their small size, nanoparticles can increase the bioavailability of poorly soluble drugs through increased dissolution rate.  Nanoparticles with high drug loadings can be achieved.  In addition, nanoparticles can be dosed through a range of administration routes, ranging from oral, intraperitoneal, intravenous, inhalation, and topical delivery.  An overview of current nanotechnology approaches, optimization of formulation parameters, and case studies will be presented.

Nanotechnology and pharmaceuticals: Harnessing drug nanoparticles for systemic drug delivery

244th National Meeting (2012)

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