We synthesized a series of new indole-tempo conjugates that were predictedto have anti-inflammatory properties. The latter was confirmed in a murine model ofxylene-induced ear edema. Moreover, we observed that these conjugates couldattenuate multiple organ injury induced by intestine ischemia/reperfusion injury. Wepropose that the pharmacological profile of our novel indole-tempo conjugates involvesconvergent roles, including the ability to decrease free radical production via lipidperoxidation coupled to a concomitant decrease in ROS (reactive oxygen species)-mediated activation of the inflammatory process.NH

Attenuation of ischemia/reperfusion-induced remote organ injury in rat using novel indole-tempol conjugates

244th National Meeting (2012)

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