When determining the limit of exposure for nanoparticles in the environment, the ability to measure nanoparticles in various media is critical in order to obtain accurate toxicology information. Sizing, 10 nm to 1 �m, and concentration measurements of particles in various media are obtained by nanoparticle tracking analysis (NTA) via particle-by-particle measurements. NTA is appropriate for screening environmental samples as the optimal concentration for detection is very low (108 particles/mL) and samples are commonly polydisperse. Recently, other parameters of detection, such as intensity, fluorescence and zeta potential, have been added to NTA, allowing for the identification of different nanoparticles within a single sample. Through combinations of these measurements, we will demonstrate with examples how NTA is a powerful, high resolution multi-parameter method with the capabilities to characterize and monitor particles in biological environments for toxicological studies and risk assessment.

Applications for fluorescence and zeta potential measurements via nanoparticle tracking analysis

244th National Meeting (2012)

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