Arsenic-72 is a 26 h half-life positron emitter (2.49 MeV) with nuclear properties useful for positron emission tomography (PET) while As-77 is a 38.8 h half-life beta emitter (0.683 MeV) potentially useful for radiotherapy applications. Utilization of these radioisotopes of As requires the development of compounds with high in vivo stability that can be conjugated to targeting probes. To this end, the reaction of p-arsanilic acid and phenyl arsonic acid with various dithiols was investigated. The compounds were analyzed by 1H and 13C NMR for both identification and stability in aqueous solution, electrospray ionization mass spectrometry (ESI-MS), and single crystal X-ray diffraction.

<sup>72,77</sup>As labeled radiopharmaceuticals for use as diagnostic imaging or therapeutic agents

244th National Meeting (2012)

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72,77As labeled radiopharmaceuticals for use as diagnostic imaging or therapeutic agents

^72,77As labeled radiopharmaceuticals for use as diagnostic imaging or therapeutic agents