Surgical resection of intra-abdominal cancers can lead to peritoneal carcinomatosis, a fatal form of metastasis where cancer cells implant on the lining of the peritoneal cavity. Prior in vivo murine studies have shown that BAY 11-7085 (1 ) induces apoptosis of colon and pancreatic cancer cells during cell adhesion. Analogs bearing the same sulfonyl acrylonitrile fragment found in 1  were prepared featuring amide and heterocyclic substitutions (2 ) and were assessed in vitro and in vivo in a murine peritoneal carcinomatosis model as potential post-operative treatments following pancreatic resection. 

Sulfonylacrylonitriles as inhibitors to peritoneal carcinomatosis

244th National Meeting (2012)

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