We report the antitumor activity of a panel of compounds largely based on 4,5-dichloroimidazole and its derivatives against various cancer cell lines, including non-small cell lung cancer lines (NCI-H460). The addition of substituents at the N-1 and N-3 positions of the imidazole precursor, especially those with planar, aromatic rings, greatly increases the antitumor activity of the complexes. This activity has been demonstrated for a variety of substituents, and for both the asymmetric and symmetric corresponding imidazolium cations. The synthesis, characterization, and MTT studies of these complexes will be discussed.

Synthesis, characterization, and antitumor activity of imidazolium cation derivatives

244th National Meeting (2012)

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