As indicated by previous results, the substitution pattern in the aniline ring plays a key role in the cytotoxic activity of 9-anilino-2-(methylthio)thiazolo[5,4-b]quinoline derivatives. To explore in more detail the structural determinants of the compound's cytotoxicity, a new series of thiazoloquinoline analogues with different substituents at 2'-position of aniline ring was synthesized and its cytotoxic activity on Hela and K-562 cell lines was tested in vitro. The biological activities recorded have been analyzed along with supporting data from molecular modeling studies of the new compounds.

Synthesis, cytotoxic activity, and molecular modeling of novel derivatives of 9-anilino-2'-substituted- thiazolo[5,4-<i>b</i>]quinoline as potential antitumor agents

244th National Meeting (2012)

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Synthesis, cytotoxic activity, and molecular modeling of novel derivatives of 9-anilino-2'-substituted- thiazolo[5,4-b]quinoline as potential antitumor agents