We first developed an efficient dynamic kinetic resolution (DKR) of a variety of racemic 2-arylpropanoic acids including Non Steroidal Anti-inflammatory Drugs (NSAIDs) using achiral alcohols with pivalic anhydride and benzotetramisole (BTM) as a chiral acyl-transfer catalyst. In this report, we investigate the substrate scope, and discuss an optimization of the reaction conditions and in situ racemization mechanism of the carboxylic acids.

Dynamic kinetic resolution of 2-arylpropanoic acids via the asymmetric esterification

244th National Meeting (2012)

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