Two types of cyclic imines were efficiently hydrogenated. (S,S)-f-Binaphane ligand has shown high reactivity and good enantioselectivity in hydrogenation of 2-arylpyrrolines along with [Ir(COD)Cl]2. A wide range of tetrahydroisoquinoline alkaloids, including the substructure of solifenacin, a pharmaceutical drug, were obtained with excellent enantioselectivities and high turnover numbers using our iridium-f-Binaphane iodine-bridged dimeric complex. The using of I2 as additive enhanced the performance of this catalyst.

Asymmetric hydrogenation of cyclic imines

244th National Meeting (2012)

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.