Our group has recently developed the concept of combined nucleophilic/anion-binding catalysis and its application to the kinetic resolution of various classes of amines.  We will discuss our recent efforts in expanding the substrate scope and improving the overall efficiency of this process.  More efficient catalytic systems have been identified through targeted structural modifications of both, the achiral nucleophilic catalyst and the chiral anion-binding co-catalyst.  This has resulted in increased selectivities while simultaneously allowing for significantly reduced catalyst loadings.

Development of anion binding approach in asymmetric catalysis

244th National Meeting (2012)

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