The platinum-catalyzed enantioselective diboration of imines is reported. This method provides a new route to chiral a-amino boronates, a class of potential active pharmaceutical agents. Good yields were achieved with up to 97:3 enantioselectivity, and the mild conditions allow the presence of multiple functional groups. One-pot reaction, including imine synthesis and diboration, was successfully developed, which enable the use of unstable imines as substrate.

Synthesis of α-amino boronates via Pt-catalyzed enantioselective diboration of imines

244th National Meeting (2012)

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