We developed a new generalized synthetic procedure, called as �heat-up process,� to produce uniform-sized nanocrystals of many transition metals and oxides without a size selection process. We were able to synthesize uniform magnetite nanocrystals as much as 1 kilogram-scale from the thermolysis of Fe-oleate complex.Extremely small 3 nm-sized iron oxide nanoparticles (ESION) were used for high resolution imaging of blood vessels of  20 nm exhibit extremely large magnetization and coercivity. The cells labeled with FIONs showed so enormous T2 contrast effect that even single cells were readily image. After transplantation of syngeneic islets, the diabetic rats became euglycemic, and the transplanted islets were observed up to 150 days. In addition, theoretically predicted maximum of r2 relaxivity was achieved by optimizing the overall size of ferrimaginetic iron oxide nanoparticles. The ferrimagnetic iron oxide nanoparticle exhibited excellent colloidal stability and was able to accumulate at the tumor after intravenous administration.We reported on the fabrication of monodisperse magnetite nanoparticles immobilized with uniform pore-sized mesoporous silica spheres for simultaneous MRI, fluorescence imaging, and drug delivery. We prepared Fe3O4/TaOx core/shell nanoparticles for simultaneous MRI and CT imaging. We synthesized hollow magnetite nanocapsules and used them for both the MRI contrast agent and magnetic guided drug delivery vehicle.Cubic phase NaGdF4:Yb,Er@NaGdF4 core@shell upconverting nanoparticles (UCNPs) were proposed as a new type of multimodal imaging probe for luminescence imaging and T1 magnetic resonance imaging (MRI). UCNPs emit visible light under NIR excitation, and they have been developed as next generation luminescent probes. The deep penetration depth of NIR as light source, excellent photostability, and absence of autofluorescence of UCNPs makes them suitable for bio-imaging and long-term tracking.

Large-scale synthesis and designed assembly of uniform-sized nanocrystals for medical applications

244th National Meeting (2012)

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