This presentation describes the synthesis of a covalently conjugated nanocomposite through self-assembly between functionalized gold nanoparticles and polymers.  Carboxylic acid-terminated gold nanoparticles were synthesized by a ligand exchange reaction of citrate-stabilized gold nanoparticles with thioctic acids, and the subsequent self-assembly of the nanoparticles with polyethyleneimine (PEI) polymer or polyamidoamine (PAMAM) dendrimer was investigated.  The condition for the formation of core-shell gold-polymer self-assembly was optimized and the self-assembled nanocomposites were covalently conjugated at the interface between gold nanoparticles and polymers.  The synthesized nanoparticles and nanocomposites were characterized by UV-vis spectrophotometry, transmission electron microscopy (TEM), dynamic light scattering (DLS), and infrared spectroscopy.  These nanocomposites are being developed for their biomedical applications such as targeted diagnostic imaging and therapy.

Preparation of covalently conjugated nanocomposites through self-assembly between functionalized gold nanoparticles and polymers

244th National Meeting (2012)

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