Peptides that bind inorganic surfaces and template the formation of nanometer-sized particles are of great interest for the self- or directed assembly of nanomaterials for sensors and diagnostics. We have developed NMR methods to determine the structure of peptides bound to metal-oxide and metal nanoparticles and report on the structure of peptides bound to silica, titania and palladium. The silica and titania binding peptides are in fast exchange and solution NMR methods can be used to determine the three dimensional structure. A compact 'C'-shaped binding motif is observed for three related peptides bound to metal-oxide surfaces. Broad lines are observed for peptides bound to palladium nanoparticles and NMR studies of alanine mutants are used to determine the low resolution structure. These methods provide an insight into the relationship between peptide sequence and function.

Peptide structure at metal-oxide and metal surfaces probed by NMR

244th National Meeting (2012)

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