Toxicity of Alzheimer's Disease A� peptide strongly depends on its interaction with Cu(II) and Zn(II) ions. Many experimental approaches have been used to elucidate and quantitate the resulting complex formation and reactivity, but no consensus has been achieved with respect to the complex stabilities. In the brain, A� peptides are released into the confined space of the glutamatergic synapse. The critically reviewed literature data, results of our experiments regarding ternary complexes formation by A� peptide and neurotransmitters and theoretical calculations of the effect of low synaptic volumes on coordination equilibria will be used to obtain a consistent view of metal ion reactivity underlying early events in Alzheimer's Disease.

Quantitative approach to Cu(II) and Zn(II) binding to Alzheimer's Aβ peptide

244th National Meeting (2012)

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