We have synthesized multiblock alternating copolymers with elastomeric properties, cell-binding capability and self-assembly potentials by condensation polymerization employing copper (I) catalyzed alyne-azide cycloaddition (CuAAC) reaction. Elastin mimetic hybrid polymers (EMHPs) composed of poly(ethylene glycol) (PEG) alternating with an alanine-rich, lysine-containing peptide, with or without the cell-binding domains, have been synthesized and characterized. Covalent cross-linking of EMHPs through the lysine amines afforded a non-toxic, cell-adhesive, elastomeric hydrogels. Separately, multiblock copolymers consisting of poly(acrylic acid) (PAA) alternating with a elastin-based peptide [(VPGVG)2 (VG2)] or poly(styrene) (PS) have also been successfully synthesized. Both [PAA-VG2]n and [PAA-PS]n self-assembled into discrete nanoparticles through the concerted interactions between the constituent building blocks. This modular hybrid system allows facile substitution of the polymer and peptide segments to add functional groups for crosslinking, biologically active domains, variations in secondary structure, pH-responsiveness and self-assembly capability for applications in tissue engineering and drug delivery.

Modular approach for the construction of multiblock alternating copolymers for biomedical applications

244th National Meeting (2012)

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