We have described the cytotoxic properties of heterometallic titanocenephosphine-M complexes of the type [Ti{?5-C5H4PPh2{MCln}x] (M = Au(I), n =1, x = 2; M = Pt(II), Pd(II), n =2, x=1). 1 We report here on the synthesis, cytotoxicity on a variety of human cancer and non cancerous cell lines and protein kinase inhibitory properties of previous and new titanocenephosphine-gold(I), palladium(II) and platinum(II) complexes containing oxalate on the Ti or thiolate ligands on the Au(I) centers (like 1-4 ). Figure 1. <img src='https://acs-archive-assets2.s3.amazonaws.com/nerm_2010/uploads/55098_at252copypbcacolor.jpg' alt='' /> 1. Contel, et al. Inorg. Chem. 2011 , 50, 11099.

Heterometallic titanocene-phosphine based TiAu2 compounds as potential chemotherapeutics and protein kinase inhibitors

244th National Meeting (2012)

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