Neuraminidase (NA) is best known for its role in proliferation of the influenza virus. Newly reported crystal structures of N1, N4 and N8 indicate the active sites of group-1 NAs are very different from group-2 NA enzymes. We believe the larger active site of group-1 NAs should be accessible to more specific and tighter-binding inhibitors. Accordingly, this presentation will detail the design, synthesis and testing of small inhibitory molecules that are specific toward group-1 neuraminidase.

Group-1 specific neuraminidase inhibitors containing an aromatic scaffold

244th National Meeting (2012)

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