A series of six novel 1,2-disubstituted-1H-benzimidazole derivatives (1-6 )    were synthesized and evaluated in vitro against the protozoa Entamoeba histolytica, Giardia intestinalis and Trichomonas vaginalis. Results show that compounds 1-6  were up to 40, 30, and 2.5 times more active than metronidazole against these parasites, respectively. The synthesis, methodology and results of the in vitro assay will be presented.

Synthesis and in vitro antiprotozoal activity of novel 1,2-disubstituted-1H-benzimidazole derivatives

244th National Meeting (2012)

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