A series of six novel substituted N-(1H-benzimidazol-2-yl)-1H-benzimidazole-5(6)-carboxamides (B1-B6  )   were synthesized and evaluated in vitro against the protozoa Entamoeba histolytica, Giardia intestinalis and Trichomonas vaginalis. Compounds B1-B6   showed more activity than metronidazole, the drug of choice against these parasites, mainly against E. histolytica. The synthesis, methodology and results of the in vitro assay will be presented

Synthesis and in vitro antiprotozoal activity of novel substituted benzimidazole carboxamides

244th National Meeting (2012)

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