Many initially promising pharmaceutical drug candidates fail because of poor absorption in the body, and the earlier such failures can be identified the better. Standard tests involve performing separate dissolution and permeability assays, the most popular being PAMPA. In this poster, we describe a low-cost combined dissolution-permeability experiment which simultaneously follows both the dissolution of a formulated pharmaceutical drug and its subsequent permeation through a lipid-coated membrane. For these studies, we have used a simple diffusion cell, guard column, peristaltic pump and UV spectrophotometer; equipment that is available in most research labs or affordable on a limited budget. The process has been automated with a macro program. Various over the counter drugs have been examined (ibuprofen, naproxen, ranitidine, phenylephrine) to date using this method. The absorption of different formulations has been compared and the results used to predict blood plasma profiles.Ibuprofen dissolution and permeation at pH 4.1

Combined dissolution–permeability experiment for simulating absorption of pharmaceutical drugs using a diffusion cell and a PC-controlled UV spectrophotometer

244th National Meeting (2012)

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