Lactosome is a core-shell type polymeric micelle, which is prepared from poly(L-lactic acid)-b-poly(sarcosine) amphiphilic block polydepsipeptide. In the assembly, hydrophobic PLLA chain forms helical structure, therefore, the polymers regularly aligned and tightly packed. Similarly to other polymeric micelles, Lactosome can encapsulate hydrophobic compounds including anticancer drugs. Further, by attaching a PLLA chain to the drugs, Lactosome can more stably encapsulate them. This is because the PLLA chain attached to the drugs can be tightly packed with Lactosome constituent polymers. Poly(lactic acid) (PLA) has three types stereoisomers of poly(L-lactic acid) (PLLA), poly(D-lactic acid) (PDLA), and poly(DL-lactic acid) (PDLLA). In this study, drug stability in Lactosome is examined by chainging attached PLA stereochemistry. As a result, it was revealed that drug release from Lactosome can be controlled by PLA stereochemistry.

Controlled drug release from polymeric micelle, Lactosome, using stereochemistry of helical components

244th National Meeting (2012)

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