n-Propane Phosphonic Acid Cyclic Anhydride (T3P�) is an exceptional reagent for amide/peptide bond formation.  T3P� has demonstrated its efficacy in the commercial scale manufacture of numerous APIs.  Novel functional group transformations have recently been achieved with T3P�, including � esterifications, the formation of nitriles, hydroxamic acids, Weinreb amides and isonitriles.  Further, T3P� has demonstrated utility in facilitating both the Curtius and Lossen rearrangements.  Oxidation of alcohols under mild conditions was also achieved with T3P�.  T3P� is very easy to use and provides excellent selectivity, low epimerization and high yields.  The desired product can be isolated by simple liquid/liquid extraction.  Because of its superior performance in coupling reactions, hazardous additives such as explosive HOBt, are not required. Numerous examples of these novel reactions will be presented, wherein the inherent advantages of T3P� will be highlighted.

T3P<sup>®</sup>: Not just for amide bond formation anymore

244th National Meeting (2012)

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T3P®: Not just for amide bond formation anymore

T3P^®: Not just for amide bond formation anymore