Hydroxamic acid functionality has been attracted for developing new small molecules against various zinc-dependent metalloenzymes due to the structural feature which is easy to coordinate with zinc metal ion in the active site of enzymes.   We have synthesized N-hydroxy-6-(thieno[3,2-b]pyridin-7-yloxy)hexanamide and N-hydroxy-3-((6-(hydroxyamino)-6-oxohexyl)oxy)benzamide.   The preliminary studies of these compounds have shown significant activities of both Anthrax metallo-beta-lactamase and histone deacetylase 8 (HDAC 8).  We will describe the design and synthesis of these compounds which would be potentials of potent inhibitors for both targets

Synthesis and evaluation of novel small molecules containing hydroxamic acid functionality with the zinc-dependent metalloenzymes such as histone deacetylase and anthrax metallo-beta-lactamase

244th National Meeting (2012)

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