The initial negative results obtained in human clinical trials analyzing synthetic MMP inhibitors stirred up the need for compounds that could be more effective in cancer treatment and this search found its answer in the field of natural compounds. One such discovery was Ageladine A, a natural product isolated from the sponge Agelas nakamurai1 that has been identified to inhibit various zinc matrixmetalloproteinases at micromolar levels. Attracted by its unique structural features and impressive biological activity, we have designed and developed a novel synthetic access to analogues of Ageladine A for the SAR studies based on Imidazopyrimidine chemistry and the results of our efforts would be presented.

Total synthesis of Ageladine A and its structural analogs via Pictet-Spengler reactions of 2-(imidazo[1,2-a]pyrimidin-2-yl)ethanamine

244th National Meeting (2012)

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.