Ibuprofen and naproxen are non-steroidal anti-inflammatory drugs with relatively short half-lives in plasma. When administered by conventional routes, severe gastrointestinal side effects occur, such as stomach ulceration, bleeding, and perforation. Drug delivery systems have been developed to localize the drug, thereby decreasing the side effects associated with systemic drug administration, and increasing the duration of the drug effect. However, major issues associated with these drug delivery systems, such as low drug loading and uncontrolled burst release, persist. In this work we present the synthesis and characterization of ibuprofen- and naproxen-based precursors for their chemical incorporation as pendant groups within poly(anhydride-ester) backbones. The subsequent polymerization of these precursors will create novel, biodegradable delivery systems with potentially higher drug loadings and more controlled release characteristics than current systems.

Ibuprofen- and naproxen-based poly(anhydride-esters): Synthesis and characterization of polymer precursors

244th National Meeting (2012)

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