Polymers have numerous biomedical applications including delivery of therapeutic materials, imaging applications, tissue regeneration, antimicrobial action and others. We have developed a route to nanogel core star polymer amphiphiles with control over size, functionality, end groups and molecular architecture. These particles can either be biostable or biodegradable depending on the desired application. These materials encapsulate hydrophobic materials such as dyes at the 10-15% level without covalent bonding. The outer shell also sequesters magnetic particles for MRI studies and ligates ions such as copper 64 for PET.  The outer shell can also be used to generate a functional silica shell or catalyze the electroless deposition of a gold shell. The later leads to a surface plasmon resonance absorption shifted into the near IR suitable for inducing hyperthermic processes in cells upon irradiation. We have also studied the antimicrobial properties of suitable substituted nanogel star polymers derivatives

Nanogel star polymers as interesting soft colloid materials for biomedical applications

244th National Meeting (2012)

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