The effect of enzymatic degradation of poly-L-lysine of different molecular weights in poly(acrylic acid) microgels is under investigation. The enzyme used in this study to degrade poly-L-lysine is Trypsin whereas the microgel that the peptide is bound to is poly(acrylic acid-co-acrylamide). The microgel charge content is controlled by varying acrylic acid/acrylamide ratios. The study investigates the protective powers that poly(acrylic acid) microgel possible give the peptide against enzymatic breakdown. Microgel deswelling and reswelling in response to peptide binding and peptide degradation is studied by micromanipulator-assisted light microscopy and confocal microscopy.

Effect of enzymatic degradation of poly-L-lysine in poly(acrylic acid-co-acrylamide) microgels

244th National Meeting (2012)

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