This presentation focuses on i) the synthesis of multifunctional nanomaterials for the delivery of various biomolecules (antibodies, siRNA etc.) and small molecules to cancer and stem cells and, ii) utilizing the functional nanomaterials as multimodal imaging and therapeutic agents against malignant tumors like glioblastoma multiforme (GBM). More specifically, the presentation demonstrates a rapid sonochemical synthetic methodology for generating a library of biocompatible ZnS-AgInS2 quantum dots (ZAIS QDs) and their application for the simultaneous delivery of small interfering RNA (siRNA) and imaging/tracking of the same in human stem cells and cancer cells. In addition, we also enlist our efforts towards the development of a polypeptide-based nanocarrier that can integrate multiple therapeutic moieties in one system. Collectively, our endeavors would facilitate the development of novel therapeutic and imaging systems aimed at the successful diagnosis and treatment of malignant cancers such as brain and breast tumors.

Multifunctional nanocarriers as imaging probes and drug and gene delivery agents in tumor cells

244th National Meeting (2012)

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