Direct analysis in real time (DART) is an ambient ionization method for mass spectrometric identification of small molecules (less than 1000 Daltons) that requires little or no sample preparation. This nondestructive technique has been widely used for forensic science and pharmaceutical applications since its introduction in 2005. We are developing methods for characterizing art and archaeological materials by use of DART with high resolution mass spectrometry. Ongoing projects involve identification of organic colorants in textiles and painted surfaces with complex matrices, screening ceramic artifacts for the presence of biomarker compounds characteristic of various organic residues, and differentiation of proteinaceous binders in glues and paints. Simple in-source derivatization or adduct formation, with or without additional sample preparation, can provide information about a wide range of materials of interest in cultural heritage studies without the need for chromatographic separation.

Applications of direct analysis in real time mass spectrometry to cultural heritage materials

245th National Meeting (2013)

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