Cellular dinitrosyl iron complexes (DNICs) have long been considered NO carriers, though their chemical functionality is not well understood. This talk will present unprecedented dioxygen reactivity and NO-releasing activity of {Fe(NO)2}10 DNICs with N-donor ligands. In the presence of O2, {Fe(NO)2}10 DNICs nitrate 2,4-di-tert-butylphenol via formation of low-temperature stable iron-peroxynitrite which isomerizes to nitrate at room temperature in the absence of phenolic substrates. On the other hand, a reaction with a one-electron outersphere oxidant leads to the formation of {Fe(NO)2}9 DNICs which slowly release NO. Spectroscopic characterizations of the reaction intermediates and products, as well as the reactions in the cellular environment will be discussed. These results suggest that DNICs have multiple physiological roles, which are influenced by various factors.References:1. Tran, N. G. et al. J. Am. Chem. Soc. 2011 , 133, 1184.2. Skodje, K. M. et al. Dalton Trans. 2012 , 41, 7849.

{Fe(NO)<sub>2</sub>}<sup>10</sup> DNICs with novel dioxygen reactivity and NO-donor capabilities

245th National Meeting (2013)

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{Fe(NO)2}10 DNICs with novel dioxygen reactivity and NO-donor capabilities

{Fe(NO)₂}¹⁰ DNICs with novel dioxygen reactivity and NO-donor capabilities