The cleavage and functionalization of C�H bonds is still a challenging conversion in part because of the lack of synthetic reagents that are active in the presence of other functional groups. These problems have been overcome in enzymes, which have metal�oxo active sites that efficiently and selectively cleave C�H bonds. How high-energy metal�oxo transient species can perform such difficult transformations with high fidelity will be the focus of this presentation.  Highlighted are the relationships between redox potentials and metal�oxo basicity on C�H bond cleavage, as observed in a series of well-characterized, bioinspired metal�oxo complexes.  The factors that govern these properties will also be discussed.

Role of metal-oxo complexes in the functionalization of C–H bonds

245th National Meeting (2013)

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