The investigation of protein-polymer or protein-nanoparticle interaction is critical for the development of novel biomaterials and hierarchically assembled nano-architectures. Among them, the polymer-protein core-shell nanoparticles (PPCS-NPs) are the most common structures which offer many advantages in the field of medicine and energy applications. Here we show that PPCS-NPs can be prepared based on synergistic interactions between proteins and synthetic polymers, a strategy learning from virus assembly. This facile and versatile process can yield structural well-controlled core-shell structures, in which proteins stay as the corona and still maintain their original biological activities. A few cases studies will be presented to highlight the application potential of such core-shell nanostructures in drug delivery, antigen presentation and enzymatic reactions.

Learning from virus: A facile route to generate core-shell nanoparticles with functional protein corona

245th National Meeting (2013)

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.