Recently, enzyme-filled polymersomes (nanoreactors) were successfully internalized in living cells. The polymersome permeability is a crucial property, since the membrane must be permeable for small molecules, but impermeable for macromolecules.We present the implementation of a therapeutically relevant enzymatic cascade in two types of polymersome-based nanoreactors to counteract oxidative stress: superoxide dismutase and catalase. The selected nanocontainers are known to possess different permeability properties. The consequences of these differences regarding the enzymatic activities were investigated by spectrophotometric and electrochemical methods.

Permeability effects on the efficiency of artificial organelles

245th National Meeting (2013)

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