Inhibition of proteolytic enzymes is an important drug design strategy. Nonhydrolyzable mimics of the hydrated amide 2  can be platforms from which to design substrate analog inhibitors. We have studied the simulation of 2  by the silanediol functional group in peptide-like structures 3  and found them to be excellent inhibitors of metallo-, aspartic and serine protease enzymes. Recent advances in inhibitor design and synthetic methods for assembling structures will be described.

Silanediol peptidomimetics as carbonyl hydrate analogs and protease inhibitors

245th National Meeting (2013)

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