BN/CC isosterism has recently emerged as a viable strategy to increase structural diversity. In particular, the chemistry of 1,2-azaborines, which are BN isosteres of the ubiquitous family of arenes, has attracted attention as novel aromatic compounds relevant to biomedical research. I will describe our recent contributions in the synthesis, characterization, and reactivity studies of 1,2-azaborine heterocycles. Furthermore, emerging investigations of 1,2-azaborines in the context of biological systems will also be discussed. 

BN/CC Isosterism:  A new approach to expand the chemical space in biomedical research

245th National Meeting (2013)

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