 Metal-catalyzed higher-order carbocyclization reactions provide an atom-economical strategy towards the construction of polycyclic ring systems. We have developed highly selective strategies for the formation of cis-fused [5,6] and [5,7] bicyclic systems. This seminar will highlight the development of the intermolecular [(3+2)+1] and [(3+2)+2] carbocyclizations utilizing alkenylidenecyclpropane (ACPs) in conjunction with carbon monoxide and allenes. Moreover, the extended scope of these transformations will be described in the context of synthetic applications.

Stereoselective rhodium(I)-catalyzed [(3+2)+1] and [(3+2)+2] carbocyclization reactions

245th National Meeting (2013)

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