Antimicrobial Peptides (AMPs) selectivly eliminate bacteria while exhibiting minimal toxicity to eukaryotic tissues.  Recently, interest in mimicking AMPs synthetically has emerged.  In this research, AMP-mimicking moieties were incorporated into copolymers in order to emulate these naturally occurring peptides. A homopolymer of N-(3-aminopropyl) methacrylamide (APMA) was synthesized via RAFT polymerization and characterized via 1H NMR and ASEC-MALLS. To convert the primary amines of PAPMA to guanidine moieties the homopolymer was reacted with N,N'-di-Boc-1H-pyrazole-1-carboxamidine (PCA) at varying primary amine to PCA ratios.

Synthesis of guanidino and primary amine functional copolymers to mimic antimicrobial peptides

245th National Meeting (2013)

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