The overlapping between polymer science and medicine is an emergent topic. Particles loaded with Bodipy or with an anti-cancer drug (Paclitaxel) were obtained with diameters around 80 � 300nm and low polydispersity, using SDS and Vitamin E-TPGS mixtures. Adhesion of particles to calcium phosphate showed dependence on polymer structure. Cell uptake studies revealed better uptake of particles with just SDS. Cytotoxicity to HeLa cells increased with the content of Vitamin E-TPGS and no cytotoxicity was evidenced with just SDS after 48h.

Poly(phosphate) nanoparticles for drug delivery systems

245th National Meeting (2013)

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