Several synthetic approaches have been designed for functionalizing water soluble Several synthetic approaches have been designed for functionalizing water soluble PEG based copolymers with imidazole moieties using the RAFT technique. One of the more versatile methods involved using the N-methacryloxy succinimide (NMS) monomer along with PEG-methacrylate to produce copolymers with variable loadings of NMS. The kinetics of this copolymerization was investigated with different ratios of the monomer and the reactivity ratios were calculated. Simple postmodification reactions with amine terminated imidazoles provided copolymers capable of attaching to CdSe based quantum dots. Other methods used involved methacylamide based imidazole monomers capable of polymerizing directly through the RAFT technique, and methacrylate based PEG monomers with imidazole groups. These techniques provide a toolbox of synthetic methodologies to precisely tailor the amount of imidazole units and have broad applicability to the loading of any amine/hydroxyl based compounds onto water soluble copolymers. Hence, the biological applicability of such polymers can be expanded to include previously incompatible moieties.

Novel synthetic approaches for imidazole functionalized copolymers

245th National Meeting (2013)

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