Olfaction plays an indispensable role in human and animals in self and environmental recognition as well as intra- and inter-specific communication. Following the discovery by Buck and Axel in 1991 of a family of odorant receptors (OR), it has been established that the sense of smell begins with the molecular recognition of a chemical odorant by one or more ORs expressed in the olfactory sensory neurons. Therefore characterization of the molecular interactions between odorant molecules and ORs is a key step in the elucidation of the general properties of the olfactory system and in the development of applications: design of new odorants, search for blockers,�The presentation will show the process putted in place in ChemCom to deorphanize and to characterize the interaction between chemical odorants and ORs. The family of human ORS includes ~400 putatively functional ORs which are GPCRs. To date over 100 hORs have been deorphanized.

Deorphanization and characterization of human odorant receptors in heterologous cells

245th National Meeting (2013)

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