Cardiovascular disease (CVD) is the leading cause of death in the world, and elevated circulating free fatty acids (FFAs) are known risk factors, however the mechanism of action is still not well understood.  Fatty acids were utilized to assess their effect on the induction of inflammation in human coronary arterial cells. Cell cultures were treated with fatty acid-enriched media, and inflammatory markers were assessed after incubation. Saturated, polyunsaturated, trans, and oxidized fatty acids were tested. Increased inflammation markers were observed for both trans and oxidized fatty acids, both compared to untreated control and their correspondent non-oxidized counterparts. The results of this study may provide an explanation to the mode of action by which trans and oxidized FFAs represent a risk factor for CVD.

Screening various free fatty acids in a model of coronary inflammation

245th National Meeting (2013)

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