Corn ethanol production involves corn starch conversion to glucose � a simple monosaccharide followed by glucose fermentation to produce ethanol. Corn ethanol by-product of distiller's dry grain with solubles (DDGS) is a rich source of resistant starch (RS). This form of the starch is resistant to human intestinal enzymes and is well utilized by colonic microorganisms. With the resistant starch isolated from DDGS, we had produced carbohydrate based nanoparticles resistant to human digestive system. Chemical composition and properties were determined using enzymatic methods in combination with high performance anion exchange chromatography (pulsed amperometric detection, HPAE-PAD), nuclear magnetic resonance (1H and H-H COSY), and X-ray diffraction (XRD). The resistant starch nanoparticles were studied using scanning electron microscopy (SEM) and atomic force microscopy (AFM). The digestive enzyme resistant nanoparticles were used as nanocoatings for the encapsulation of selected mineral nutrients, nutraceutical, and pharmaceuticals. The chemical and physical stabilities of RS encapsulated materials were tested under simulating human digestive environment. Results of the present study clearly show potential of corn DDGS RS as a carbohydrate based nanomaterial for micronutrient and pharmaceutical drug delivery.

Corn resistant starch nanoparticles as encapsulation material for micronutrient and pharmaceutical drug delivery

245th National Meeting (2013)

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.