Antibody structures such as specific Glycan profile and charge variants are considered important quality attributes for their certain biological activities.  These quality attributes may be impacted by cell culture bioprocess conditions.  Many have explored methods to keep the antibody quality attributes consistent and have successfully implemented the methods in antibody process development.  It is considered more challenging to try to target a specific quality attribute of an antibody in development within a desired range with a flexible methodology that is not in conflict to the direction of developing higher productivity.  In this presentation, we intend to demonstrate a few methodologies applied effectively in targeting specific antibody quality attribute profile while maintaining or advancing productivity.

Effective methodologies to target antibody quality attributes in cell culture process development

245th National Meeting (2013)

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